abstract：AIMS:Polymorphous low-grade adenocarcinoma (PLGA) is the second most common type of malignant neoplasm in minor salivary glands. Its origin in major salivary glands is considered exceedingly rare. Herein, we present three cases of de novo PLGA arising in major salivary glands. METHODS AND RESULTS:Three cases of PLGA w...

journal_title：Histopathology

authors： Nagao T,Gaffey TA,Kay PA,Minato H,Serizawa H,Lewis JE

更新日期：2004-02-01 00:00:00

abstract：AIMS:Some experimental evidence suggests that in lung cancer, development, progression and an increased proliferation rate can be linked to apoptosis-related factors. In this study we evaluated the possible role of p53 and Bcl-2 gene family members as prognostic factors for non-small-cell lung cancer. METHODS AND RESU...

journal_title：Histopathology

authors： Groeger AM,Esposito V,De Luca A,Cassandro R,Tonini G,Ambrogi V,Baldi F,Goldfarb R,Mineo TC,Baldi A,Wolner E

更新日期：2004-01-01 00:00:00

abstract：:The detailed documentation of ocular pathology has become an important component in the autopsy investigation of suspected cases of non-accidental injury in infants and young children. Careful histological examination of retinal haemorrhages is of critical importance, but there remains debate about the significance of...

journal_title：Histopathology

authors： Gilliland MG,Luthert P

更新日期：2003-12-01 00:00:00

abstract：AIMS:To undertake a clinicopathological study of diffuse serosal neoplasms of epithelial histogenesis which clinically and pathologically mimic malignant pleural mesothelioma. METHODS AND RESULTS:Over a 10-year (1990-2000) study period 53 carcinomas mimicking diffuse pleural mesothelioma ('pseudomesotheliomatous' carc...

journal_title：Histopathology

authors： Attanoos RL,Gibbs AR

更新日期：2003-11-01 00:00:00

abstract：AIMS:To investigate the prognostic significance of chromosomal alterations in colorectal cancer patients. Histopathological tumour classification is still considered to be the gold standard for the characterization of solid tumours. However, it is well known that such established parameters do not satisfactorily predic...

journal_title：Histopathology

authors： Knösel T,Schlüns K,Stein U,Schwabe H,Schlag PM,Dietel M,Petersen I

更新日期：2003-10-01 00:00:00

abstract：AIMS:To investigate the immunohistochemical expression of KDR/flk-1 in a series of 114 urothelial bladder carcinomas in relation to clinicopathological parameters, Ki67, p53 and Bcl-2 protein expression and patient survival. KDR/flk-1 is a high-affinity tyrosine kinase receptor for vascular endothelial growth factor (V...

journal_title：Histopathology

authors： Gakiopoulou-Givalou H,Nakopoulou L,Panayotopoulou EG,Zervas A,Mavrommatis J,Giannopoulos A

更新日期：2003-09-01 00:00:00

abstract：AIMS:To investigate whether localization of beta-catenin is helpful in differentiating primary ovarian mucinous carcinoma and colorectal adenocarcinoma metastatic to the ovary. Extra-ovarian cancers which metastasize to the ovaries, especially from colorectal adenocarcinoma, frequently mimic primary ovarian carcinomas,...

journal_title：Histopathology

authors： Chou YY,Jeng YM,Kao HL,Chen T,Mao TL,Lin MC

更新日期：2003-08-01 00:00:00

abstract：AIMS:Angiogenesis is an important factor in tumour growth and metastasis. Vascular endothelial growth factor receptor 2 (VEGFR-2) or KDR plays a crucial role in angiogenesis. The aim of this study was to raise and characterize antibodies against phosphorylated KDR which could be used for studies on human tissues to ass...

journal_title：Histopathology

authors： Stewart M,Turley H,Cook N,Pezzella F,Pillai G,Ogilvie D,Cartlidge S,Paterson D,Copley C,Kendrew J,Barnes C,Harris AL,Gatter KC

更新日期：2003-07-01 00:00:00

abstract：AIMS:The purpose of this study was to examine the occurrence of CD44 isoforms in breast carcinomas and their role in predicting clinical outcome. METHODS AND RESULTS:Shock-frozen tumour tissues from 110 patients with breast carcinoma were examined by immunohistochemistry using antibodies directed against CD44s, v5, v6...

journal_title：Histopathology

authors： Berner HS,Suo Z,Risberg B,Villman K,Karlsson MG,Nesland JM

更新日期：2003-06-01 00:00:00

abstract：AIMS:To compare the morphological and immunohistochemical characteristics of oestrogen receptor (ER)-negative and ER-positive ductal carcinoma in situ (DCIS) of the breast, in an attempt to establish more objective criteria for the classification of DCIS. METHODS AND RESULTS:Sections of 64 cases of in-situ carcinoma o...

journal_title：Histopathology

authors： Baqai T,Shousha S

更新日期：2003-05-01 00:00:00

abstract：AIMS:We present three distinctive uterine tumours which exhibited immature smooth muscle differentiation mimicking smooth muscle cells of the fetal uterus. METHODS AND RESULTS:The patients were 45, 46 and 49 years old, and all of them had simple hysterectomies. Grossly, all tumours were present in the uterine body, an...

journal_title：Histopathology

authors： Watanabe K,Ogura G,Suzuki T

更新日期：2003-04-01 00:00:00

abstract：AIMS:Spermatocytic seminoma is a rare germ cell derived tumour of the testis that occurs mainly in older men. We analysed the expression of recently discovered markers for germ cell differentiation and the mitosis-meiosis transition in order to define the antigen profile for diagnostic purposes and to clarify the biolo...

journal_title：Histopathology

authors： Rajpert-De Meyts E,Jacobsen GK,Bartkova J,Aubry F,Samson M,Bartek J,Skakkebaek NE

更新日期：2003-03-01 00:00:00

abstract：AIMS:Progressive changes have been reported in lymph nodes in HIV infection, but few accounts describe altered splenic histology at different stages of the disease. Investigation of splenic changes accompanying the progressive CD4+ T-cell depletion that occurs in HIV infection could shed light on normal immunological i...

journal_title：Histopathology

authors： Wilkins BS,Davis Z,Lucas SB,Delsol G,Jones DB

更新日期：2003-02-01 00:00:00

abstract：AIMS:Focal nodular hyperplasia-like lesions have rarely been described in cirrhotic livers. We describe five cases of such lesions. METHODS AND RESULTS:Between 1998 and 2001, 146 liver transplants were performed at the Royal Free Hospital for cirrhosis of the liver. Nodular lesions identified in the livers removed at ...

journal_title：Histopathology

authors： Quaglia A,Tibballs J,Grasso A,Prasad N,Nozza P,Davies SE,Burroughs AK,Watkinson A,Dhillon AP

更新日期：2003-01-01 00:00:00

abstract：AIMS:The study was undertaken to demonstrate wild-type p53 in normal paraffin-embedded tissues using two widely used antibodies, DO7 and 1801 and two different antigen retrieval buffer systems. METHODS AND RESULTS:Formalin-fixed paraffin-embedded normal tissue samples were obtained from the archives of the John Radcli...

journal_title：Histopathology

authors： Pillai G,Roberts H,Gatter K,Pezzella F

更新日期：2003-01-01 00:00:00

abstract：AIMS:Most primary gastrointestinal lymphomas are of B-cell origin and T-cell origin is very rare. Recent studies have suggested that human T-cell lymphotrophic virus type 1 (HTLV-1) may be involved in the development of primary gastric T-cell lymphoma. We analysed 31 patients with primary gastric T-cell lymphoma in sou...

journal_title：Histopathology

authors： Hatano B,Ohshima K,Katoh A,Kanda M,Kawasaki C,Tsuchiya T,Shimazaki K,Haraoka S,Sugihara M,Suzumiya J,Kikuchi M

更新日期：2002-11-01 00:00:00

abstract：:The classification of renal cell neoplasms has been extensively studied in the last decade, and a standardized nomenclature adopted. Although this system is based on a combination of genetic, histological and immunohistological features, in most cases accurate classification can be based on histological features alone...

journal_title：Histopathology

authors： Renshaw AA

更新日期：2002-10-01 00:00:00

abstract：AIM:We evaluated the aetiology of ulcerative ileitis in a 77-year-old patient receiving BCG therapy for recurring bladder carcinoma. METHODS AND RESULTS:Histological examination, laboratory data and the clinical history allowed us to exclude a classical cause such as Crohn's disease, tuberculosis or ischaemia. The imp...

journal_title：Histopathology

authors： Satgé D,Pommepuy I,Hassan T,Goburdhun J,Flejou JF

更新日期：2002-09-01 00:00:00

abstract：AIMS:We tried to improve the evaluation of E-cadherin immunostaining in paraffin sections, to distinguish the less aggressive variants of ductal infiltrating breast cancer from other variants. METHODS AND RESULTS:The method graded the membrane staining and estimated the fraction of area of cancer tissue stained at the...

journal_title：Histopathology

authors： Elzagheid A,Kuopio T,Ilmen M,Collan Y

更新日期：2002-08-01 00:00:00

abstract：AIMS:To develop a method to preserve lipids in formalin-fixed tissues for staining in paraffin sections, and to illustrate its use in lung and brain of a fat embolism case, and in examples of fatty liver and atheroma. METHODS AND RESULTS:A saturated solution of linoleic acid in 70% ethylene glycol was prepared and tis...

journal_title：Histopathology

authors： Tracy RE,Walia P

更新日期：2002-07-01 00:00:00

abstract：AIMS:We sought to delineate and describe three cases of a distinctive mesenchymal neoplasm of the vulva showing adipocytic differentiation and affecting young patients. METHODS AND RESULTS:In three patients between 13 and 38 years of age, the vulvar tumours had well-circumscribed borders and ranged in size from 35 to ...

journal_title：Histopathology

authors： Lae ME,Pereira PF,Keeney GL,Nascimento AG

更新日期：2002-06-01 00:00:00

abstract：AIMS:Prognostic factors affecting survival in cases of leiomyosarcoma of soft parts were investigated in this study. METHODS AND RESULTS:A retrospective study of 267 patients was carried out. This group comprised 142 females (53%) and 125 males (47%), whose ages ranged from 7 to 95 years (median 58 years). One hundred...

journal_title：Histopathology

authors： Miyajima K,Oda Y,Oshiro Y,Tamiya S,Kinukawa N,Masuda K,Tsuneyoshi M

更新日期：2002-04-01 00:00:00

abstract：AIMS:We present the histopathological findings of a series of six cases of a benign uterine smooth muscle tumour with an unusual growth pattern. METHODS AND RESULTS:All cases have the appearances of the recently described dissecting (cotyledonoid) leiomyoma. In addition, three of these lesions demonstrate the features...

journal_title：Histopathology

authors： Jordan LB,Al-Nafussi A,Beattie G

更新日期：2002-03-01 00:00:00

abstract：AIMS:A variety of histological variants of thymic carcinoid tumour have been described. A rare case of pigmented spindle cell carcinoid tumour of the thymus is documented and compared with the reported cases of thymic pigmented carcinoid tumour in the literature, with a discussion of the differential diagnosis of spind...

journal_title：Histopathology

authors： Kuo TT

更新日期：2002-02-01 00:00:00

abstract：AIMS:To investigate the relation of fatty acid synthase (FAS) expression to the clinicopathological characteristics of gastric cancers and gastric tumorigenesis. METHODS AND RESULTS:FAS expression was examined immunohistochemically in 626 gastric cancers, 51 gastric adenomas, and non-neoplastic epithelium contiguous w...

journal_title：Histopathology

authors： Kusakabe T,Nashimoto A,Honma K,Suzuki T

更新日期：2002-01-01 00:00:00

abstract：AIMS:Members of the cadherin and catenin families are involved in chondrogenesis and catenin gene mutations have been detected in malignant tumours of bone. This study was undertaken to assess in detail expression of cadherin, beta-catenin and the associated tumour suppressor gene product APC in bone and cartilage at d...

journal_title：Histopathology

authors： Monaghan H,Bubb VJ,Sirimujalin R,Millward-Sadler SJ,Salter DM

更新日期：2001-12-01 00:00:00

abstract：:This article considers the issues of image manipulation within the context of electronic/digital images. The possibility for such alterations has occurred with the increasing availability of simple and cheap computer software, permitting modification of digitized images as a whole, or in part. The concepts of acceptab...

journal_title：Histopathology

authors： Suvarna SK,Ansary MA

更新日期：2001-11-01 00:00:00

abstract：AIMS:Extraskeletal myxoid chondrosarcoma is a rare low-grade soft-tissue sarcoma with locally aggressive and metastasizing potential. Extraskeletal myxoid chondrosarcoma has distinctive clinical, light microscopic, immunophenotypic, cytogenetic and ultrastructural features. Evidence that extraskeletal myxoid chondrosar...

journal_title：Histopathology

authors： Goh YW,Spagnolo DV,Platten M,Caterina P,Fisher C,Oliveira AM,Nascimento AG

更新日期：2001-11-01 00:00:00

abstract：AIMS:To document the clinical, light microscopic, immunohistochemical and ultrastructural features of four cases of extra-orbital giant cell angiofibromas. METHODS AND RESULTS:Sections of formalin-fixed paraffin-embedded specimens were studied by haematoxylin and eosin, reticulin and immunohistochemical stains. Electr...

journal_title：Histopathology

authors： Thomas R,Banerjee SS,Eyden BP,Shanks JH,Bisset DL,Hunt R,Byers RJ,Oogarah P,Harris M

更新日期：2001-10-01 00:00:00

abstract：AIMS:To characterize the clinicopathological features and biological potential of a group of soft tissue lesions with morphology intermediate between intramuscular myxoma and low-grade myxofibrosarcoma. METHODS AND RESULTS:Thirty-eight lesions in 37 patients were retrieved from the authors' consultation files. Clinica...

journal_title：Histopathology

authors： van Roggen JF,McMenamin ME,Fletcher CD

更新日期：2001-09-01 00:00:00

abstract：AIMS:The cadherin-catenin complex is known to play a critical role in maintenance of cell adhesion. Additionally beta-catenin (beta-ct) can also take part in signal transduction and nuclear beta-ct expression could be correlated with poor prognosis in several malignancies. Since, in gastric cancer, this role of beta-ct...

journal_title：Histopathology

authors： Grabsch H,Takeno S,Noguchi T,Hommel G,Gabbert HE,Mueller W

更新日期：2001-08-01 00:00:00

abstract：AIMS:We report the clinicopathological and immunohistochemical characteristics of 12 cases of a recently recognized entity, oncocytic papillary thyroid carcinoma (PC) with lymphoid stroma (Warthin-like tumour). METHODS AND RESULTS:The cases were retrieved from the surgical pathology files of our departments. There wer...

journal_title：Histopathology

authors： Ludvíková M,Ryska A,Korabecná M,Rydlová M,Michal M

更新日期：2001-07-01 00:00:00

abstract：AIMS:Although delayed hypopituitarism is a common complication of conventional radiotherapy of sellar tumours, histological changes that may account for it have been rarely reported. To elucidate the changes, hypofunctional pituitary glands following irradiation were studied. METHODS AND RESULTS:Two pituitary glands o...

journal_title：Histopathology

authors： Nishioka H,Ito H,Haraoka J,Hirano A

更新日期：2001-06-01 00:00:00

abstract：AIMS:Pulmonary artery (PA) dissection is a rare event which usually occurs in patients with underlying pulmonary hypertension. We describe two patients who developed PA dissection without pre-existing pulmonary hypertension and present an extensive review of the literature. METHODS AND RESULTS:In the first patient (a ...

journal_title：Histopathology

authors： Inayama Y,Nakatani Y,Kitamura H

更新日期：2001-05-01 00:00:00

abstract：AIMS:Sixty new cases of human dirofilariasis due to Dirofilaria repens, occurring in Italy between 1990 and 1999, are presented. This is the most extensive case study of this zoonosis reported worldwide by a single study group. The aim is to utilize this large experience to characterize the different histopathological ...

journal_title：Histopathology

authors： Pampiglione S,Rivasi F,Angeli G,Boldorini R,Incensati RM,Pastormerlo M,Pavesi M,Ramponi A

更新日期：2001-04-01 00:00:00

abstract：AIMS:Multidrug resistance (MDR) is a major obstacle in the treatment of lymphoma. The expression of MDR-1 mRNA and P-glycoprotein (MDR-1/P-gp) has been linked to MDR. We aimed to investigate the expression of MDR-1/P-gp in B-cell lymphoma. METHODS AND RESULTS:Samples at diagnosis and relapse from 10 patients with B-ce...

journal_title：Histopathology

authors： Liu Q,Ohshima K,Kikuchi M

更新日期：2001-03-01 00:00:00

abstract：:The recognition of recurrent genetic alterations in specific tumour types has provided the basis for the reclassification of certain soft tissue neoplasms, and molecular analysis of patient material has the potential to provide both diagnostic and prognostic information. In this review, we evaluate the role of molecul...

journal_title：Histopathology

authors： Pfeifer JD,Hill DA,O'Sullivan MJ,Dehner LP

更新日期：2000-12-01 00:00:00

abstract：AIMS:Pulmonary fibrosis in acute and chronic lung disease has been much investigated, but little attention has been directed at the elastic tissue in these situations. Our aim was to verify whether elastic deposition accompanies collagen deposition in the repairing process of acute and chronic lung injury. METHODS AND...

journal_title：Histopathology

authors： Negri EM,Montes GS,Saldiva PH,Capelozzi VL

更新日期：2000-11-01 00:00:00

abstract：:The differential diagnosis of melanocytic lesions is fraught with difficulty and a common source of litigation either if a lesion misreported as 'benign' recurs locally or re-presents with nodal metastases or if an atypical naevus is called 'malignant' leading to a cosmetically unsatisfactory wider resection, unwarran...

journal_title：Histopathology

authors： Okun MR,Edelstein LM,Kasznica J,Kirkham N,Slater DN

更新日期：2000-11-01 00:00:00

abstract：AIMS:Eleven cases of cutaneous perineurioma were studied to further characterize the histological features of this entity. METHODS AND RESULTS:The histological and immunocytochemical features of 11 cases of cutaneous perineurioma were studied and detailed by two pathologists. Clinical data were obtained from the refer...

journal_title：Histopathology

authors： Robson AM,Calonje E

更新日期：2000-10-01 00:00:00